Editorial: Emerging Therapeutic Approaches for Cystic Fibrosis

Editorial: Emerging Molecular Targets for the Treatment of Cystic Fibrosis.

Cystic fibrosis (CF) is a deadly autosomal recessive disease characterized by airway obstruction, infection, inflammation, and eventually end-stage lung failure. It is the most common life-shortening genetic disorder in Caucasians, and caused by mutations in the gene that encodes the CF transmembrane conductance regulator (CFTR). This disease affects approximately 70,000 individuals worldwide a...

Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis

During development and wound healing, physiological fibrogenesis maintains connective tissue integrity and structure through synthesis of extracellular matrix (ECM). However, although many organs have a capacity to repair and regenerate after acute or mild injury, severe or ongoing stress results in fibrosis, which refers to the overgrowth, hardening, and scarring of tissues and ultimately caus...

Editorial – Journal of Cystic Fibrosis

CYSTIC FIBROSIS Burkholderia pseudomallei: another emerging pathogen in cystic fibrosis

Background: Burkholderia pseudomallei is an important cause of acute fulminant pneumonia and septicaemia in tropical regions of northern Australia and south east Asia. Subacute and chronic forms of the disease also occur. There have been three recent reports of adults with cystic fibrosis (CF) who presumably acquired B pseudomallei infection during extended vacations or residence in either Thai...

Cystic Fibrosis: Therapeutic Options For Co-management

Cystic fibrosis (CF) is a cruel and deadly disease affecting the respiratory system, digestive system, endocrine system, and reproductive system. CF is a disease of greatly varied symptomatology due to the many possible mutations contributing to genotype and phenotype. This creates a disease complex with a wide range of disorders that can ultimately include chronic obstructive pulmonary disease...